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biological source
human
Quality Level
recombinant
expressed in E. coli
form
liquid
concentration
1 mg/mL
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... H1.0(3005)
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General description
Histone H1 is part of high-order chromatin structure and is a linker protein associated with nucleosome core particle. Histone H1 is mapped to human chromosome 6. Histone H1 exists in different isoforms. Histone H1 comprises of N-terminal hydrophobic rich region, central globular domain and a C-terminal with intrinsically disordered regions.
Biochem/physiol Actions
The C-terminal regions of histone H1 is essential for binding to chromatin. The placement of H1 is necessary for nucleosome positioning. Histone H1 maintains chromosome architecture and stabilises compaction of nucleosomes during interphase. H1-null mutants display increased rate of chromatin aberration and growth defects. Histone H1 modulates embryogenesis and DNA repair. The H1 histone undergoes posttranslational modification including phosphorylation, methylation and acetylation, each of which carry out different physiological functions. Histone H1 and its variants contribute to the pathogenesis in cancer, Alzheimer′s disease, male infertility and immunity related disorders.
Physical form
Supplied as 1 mg/mL in 20 mM NaPO4, pH 7.0, 0.3 M NaCl, 1 mM EDTA, and 1 mM DTT.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
H1 histones: current perspectives and challenges
Harshman SW, et al.
Nucleic Acids Research, 41(21), 9593-9609 (2013)
Histone H1 null vertebrate cells exhibit altered nucleosome architecture
Hashimoto H, et al.
Nucleic Acids Research, 38(11), 3533-3545 (2010)
The H1 linker histones: multifunctional proteins beyond the nucleosomal core particle
Hergeth SP and Schneider R
EMBO Reports, 16(11), 1439-1453 (2015)
Dynamic placement of the linker histone H1 associated with nucleosome arrangement and gene transcription in early Drosophila embryonic development
Hu J, et al.
Cell Death & Disease, 9(7), 765-765 (2018)
Linker Histone in Diseases
Ye X, et al.
International Journal of Biological Sciences, 13(8), 1008-1018 (2017)
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