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About This Item
Empirical Formula (Hill Notation):
HCl
CAS Number:
Molecular Weight:
36.46
MDL number:
UNSPSC Code:
12352301
PubChem Substance ID:
NACRES:
NA.21
Recommended Products
form
liquid
Quality Level
concentration
3.80-4.40 M (by NaOH, titration)
4.0 M in dioxane
density
1.05 g/mL at 25 °C
SMILES string
Cl
InChI
1S/ClH/h1H
InChI key
VEXZGXHMUGYJMC-UHFFFAOYSA-N
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General description
Hydrogen chloride solution contains 4.0 M hydrogen chloride in 1,4-dioxane as the solvent. It is commonly used as a deprotection reagent during the deprotection of the tert-butoxycarbonyl (Boc) group of various amino acids and peptides. Additionally, it serves as a reagent in various organic synthesis reactions, including the synthesis of N-9-Fluorenylmethoxycarbonyl- (Fmoc) amino-acid chlorides.
Application
Hydrogen chloride solution (4.0 M in dioxane) can be used as:
- A reagent for the deprotection of the N-Boc protecting group from various heterocyclic derivatives.
- A reagent for the deprotection of polymer protecting groups. For instance, deprotection of benzyl ether-protected polymer.
- A polymerization initiator in combination with ZnCl2 in the synthesis of formyl terminated poly(ethyl vinyl ether) from ethyl vinyl ether (EVE).
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2 - Met. Corr. 1 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Supplementary Hazards
Storage Class Code
3 - Flammable liquids
WGK
WGK 3
Flash Point(F)
62.6 °F - closed cup
Flash Point(C)
17 °C - closed cup
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