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MABS36

Sigma-Aldrich

Anti-ODC1 Antibody, clone CPTC-ODC1-2

clone CPTC-ODC1-2, from mouse

Synonym(s):

ornithine decarboxylase 1, ornithine decarboxylase

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

CPTC-ODC1-2, monoclonal

species reactivity

human

technique(s)

western blot: suitable

isotype

IgG2aκ

NCBI accession no.

NP_002530

UniProt accession no.

P11926

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... ODC1(4953)

General description

Ornithine decarboxylase (ODC1) is the first enzyme in polyamine synthesis and is mandatory for normal growth and is increased in many types of cancers. ODC1 has been shown to suppress the fmc1 deletion in yeast and restores healthy respiratory growth. ODC1 may play a role in promoting DNA synthesis in hepatocytes.

Immunogen

Full length of recombinant protein corresponding to human ODC1.

Material obtained from the National Cancer Institute’s Clinical Proteomic Technologies for Cancer (CPTC) program.

Application

Research Category
Signaling
This Anti-ODC1 Antibody, clone CPTC-ODC1-2 is validated for use in WB for the detection of ODC1.

Quality

Evaluated by Western Blot in MCF-7 cell lysate.

Western Blot Analysis: 10 µg/mL of this antibody detected ODC1 on 10 µg of MCF-7 cell lysate.

Target description

~51 kDa observed. A band at ~100 kDa may be observed in some lysates and may be the homodimer of this protein.

Physical form

Format: Purified
Protein G
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
MCF-7 cell lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Guillaume N Fiches et al.
PLoS pathogens, 18(4), e1010503-e1010503 (2022-04-30)
Polyamines are critical metabolites involved in various cellular processes and often dysregulated in cancers. Kaposi's sarcoma-associated Herpesvirus (KSHV), a defined human oncogenic virus, leads to profound alterations of host metabolic landscape to favor development of KSHV-associated malignancies. In our studies
Milind D Chalishazar et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 25(16), 5107-5121 (2019-06-06)
Small-cell lung cancer (SCLC) has been treated clinically as a homogeneous disease, but recent discoveries suggest that SCLC is heterogeneous. Whether metabolic differences exist among SCLC subtypes is largely unexplored. In this study, we aimed to determine whether metabolic vulnerabilities

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