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MAB427

Sigma-Aldrich

Anti-Dihydropyridine-sensitive Calcium Channel α 1 Subunit Antibody, clone 1a

ascites fluid, clone mAB 1a, Chemicon®

Synonym(s):

Anti-CACNL1A3, Anti-CCHL1A3, Anti-Cav1.1, Anti-HOKPP, Anti-HOKPP1, Anti-MHS5, Anti-TTPP1, Anti-hypoPP

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

ascites fluid

antibody product type

primary antibodies

clone

mAB 1a, monoclonal

species reactivity

rabbit, mouse, human, rat

manufacturer/tradename

Chemicon®

technique(s)

flow cytometry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_000069.2

UniProt accession no.

Q13698

shipped in

dry ice

target post-translational modification

unmodified

Specificity

Dihydropyridine calcium channel, a1 subunit as determined by Western blot (~210 kDa), immunoprecipitation and functional test. Membrane preparations are recommended. The mouse muscle cell line, BC3H1 functions as a good positive control cell line. Reactive with L-type calcium channel alpha1 subunit. Specific for small cell carcinoma and neuroblastoma by FACS analysis. No interaction with squamous cell carcinoma or with cardiac calcium chanel isoforms.

Application

Anti-Dihydropyridine-sensitive Calcium Channel α 1 Subunit Antibody, clone 1a is an antibody against Dihydropyridine-sensitive Calcium Channel α 1 Subunit for use in FC, IP & WB.
Western blot, immunoprecipitation and FACS.

Optimal working dilutions must be determined by end user.

Linkage

Replaces: 06-422

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Isoform switching in myofibrillar and excitation-contraction coupling proteins contributes to diminished contractile function in regenerating rat soleus muscle.
Esposito, A; Germinario, E; Zanin, M; Palade, PT; Betto, R; Danieli-Betto, D
Journal of Applied Physiology (1985)
Monoclonal antibody to the alpha 1-subunit of the dihydropyridine-binding complex inhibits calcium currents in BC3H1 myocytes.
Morton, M E, et al.
The Journal of Biological Chemistry, 263, 613-616 (1988)
R G Parton et al.
The Journal of cell biology, 136(1), 137-154 (1997-01-13)
Caveolae, flask-shaped invaginations of the plasma membrane, are particularly abundant in muscle cells. We have recently cloned a muscle-specific caveolin, termed caveolin-3, which is expressed in differentiated muscle cells. Specific antibodies to caveolin-3 were generated and used to characterize the
Localization of Cacna1s to ON bipolar dendritic tips requires mGluR6-related cascade elements.
Tummala, SR; Neinstein, A; Fina, ME; Dhingra, A; Vardi, N
Investigative Ophthalmology & Visual Science null
Calcium channels are involved in calcium oxalate crystal formation in specialized cells of Pistia stratiotes L.
Volk, GM; Goss, LJ; Franceschi, VR
Annals of Botany null
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