5.00299

Nicotinamide

EMPROVE^® ESSENTIAL, Ph. Eur., BP, JP, USP, FCC

• Synonym(s): Nicotinamide, Nicotinamide, Niacinamide, 3-Pyridinecarboxamide
• Empirical Formula (Hill Notation): C₆H₆N₂O
• CAS Number: 98-92-0
• Molecular Weight: 122.12
• MDL number: MFCD00006395
• UNSPSC Code: 12352111
• EC Index Number: 202-713-4

Properties

• Agency: BP; JP; Ph. Eur.; USP
• Quality Level: 500
• reg. compliance: FCC
• description: EMPROVE^® ESSENTIAL Ph Eur,BP,USP,JP,FCC
• product line: EMPROVE^® ESSENTIAL
• form: solid
• autoignition temp.: 480 °C
• potency: 3530-3540 mg/kg LD₅₀, oral (Rat); >2000 mg/kg LD₅₀, skin (Rabbit)
• technique(s): API processing | cocrystal formation: suitable
• pH: 6.0-7.5 (20 °C, 50 g/L in H₂O)
• bp: 150-160 °C/0.0007 hPa
• mp: 128-131 °C (sublimed)
• transition temp: flash point 182 °C
• density: 1.40 g/cm³ at 20 °C
• application(s): liquid formulation; pharmaceutical; solid formulation
• storage temp.: 15-25°C
• InChI: 1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
• InChI key: DFPAKSUCGFBDDF-UHFFFAOYSA-N

Description

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Nicotinamide is a commonly used ingredient in food and pharmaceutical applications. In pharmaceutical formulations, nicotinamide has been used for a range of different dosage forms.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H319
• Precautionary Statements: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): 302.0 °F - closed cup
• Flash Point(C): 150 °C - closed cup