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368050

Sigma-Aldrich

Granzyme B Inhibitor I

≥95% (HPLC), solid, Granzyme B inhibitor, Calbiochem®

Synonym(s):

Granzyme B Inhibitor I, Z-AAD-CMK

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About This Item

Empirical Formula (Hill Notation):
C19H24ClN3O7
Molecular Weight:
441.86
UNSPSC Code:
12352200
NACRES:
NA.77

product name

Granzyme B Inhibitor I, The Granzyme B Inhibitor I controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.

Quality Level

100

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

color

off-white

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

A weak inhibitor of the human and murine granzyme B. Also inhibits the apoptosis-related DNA fragmentation in lymphocytes by fragmentin 2, a rat lymphocyte granule protease homologous to granzyme B (ID50 = 300 nM).
A weak inhibitor of the human and murine serine protease granzyme B. Also inhibits the apoptosis related DNA fragmentation in lymphocytes by fragmentin 2, a rat lymphocyte granule protease homologous to granzyme B (ID50 = 300 nM).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Granzyme B
Product does not compete with ATP.
Reversible: no
Target IC50: 300 nM against the apoptosis-related DNA fragmentation in lymphocytes by fragmentin 2

Warning

Toxicity: Standard Handling (A)

Sequence

Z-Ala-Ala-Asp-CH₂Cl

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Gong, B., et al. 1999. Cell Growth Different. 10, 491.
Shi, L., et al. 1992. J. Exp. Med. 176, 1521.
Odake, S., et al. 1991. Biochemistry30, 2217.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ning-Ning Ji et al.
Frontiers in neurology, 10, 1306-1306 (2020-01-11)
Hippocampal neuronal apoptosis is a devastating consequence of cardiac arrest (CA) and subsequent cardiopulmonary resuscitation (CPR). In this study, we assessed the contribution of cytotoxic T lymphocyte (CTL)-derived toxic mediator granzyme B (Gra-b) to the hippocampal neuronal apoptosis following CA/CPR

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