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860676P

Avanti

C16 Ceramide-d7 (d18:1-d7/16:0)

Avanti Research™ - A Croda Brand 860676P, powder

Synonym(s):

N-palmitoyl-D-erythro-sphingosine (d7)

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About This Item

Empirical Formula (Hill Notation):
C34H60D7NO3
CAS Number:
1840942-13-3
Molecular Weight:
544.94
UNSPSC Code:
12352100
NACRES:
NA.12

form

powder

packaging

pkg of 1 × 1 mg (860676P-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860676P

shipped in

dry ice

storage temp.

−20°C

SMILES string

OC[C@]([H])(NC(CCCCCCCCCCCCCCC)=O)[C@@](O)([H])/C=C/CCCCCCCCCCC(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H]

General description

C16 Ceramide (d18:1/16:0) is a synthetic ceramide containing sphingosine with palmitic acid. It is synthesized from ceramide synthase 6 (CerS6). C16 Ceramide-d7 (d18:1-d7/16:0) is a deuterated derivative of ceramide d18:1/16:0.

Application

C16 Ceramide-d7 (d18:1-d7/16:0), has been used as a standard to measure the amount of C16 ceramide in skeletal muscle by liquid chromatography–mass spectrometry (LC-MS).

Biochem/physiol Actions

C16 Ceramide plays a vital role in apoptotic signaling. Examining the levels of the ceramides (Cer) d18:1/16:0, Cer d18:1/18:0, Cer d18:1/24:0, and Cer d18:1/24:1 and ratios in human plasma facilitates the prognosis of fatal outcome of coronary artery disease. A newly described and validated liquid chromatography-tandem mass spectrometry methodology uses C16 Ceramide (d18:1/16:0) in a stable isotope form for their clinical-scaled measurement.

Packaging

5 mL Amber Glass Screw Cap Vial (860676P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

Flash Point(F)

No data available

Flash Point(C)

No data available

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Dimple Kauhanen et al.
Analytical and bioanalytical chemistry, 408(13), 3475-3483 (2016-02-29)
Monitoring the levels of the ceramides (Cer) d18:1/16:0, Cer d18:1/18:0, Cer d18:1/24:0, and Cer d18:1/24:1 and ratios thereof in human plasma empowers the prediction of fatal outcome of coronary artery disease (CAD). We describe a validated liquid chromatography-tandem mass spectrometry
Anna Zalewska et al.
Biomolecules, 9(12) (2019-12-19)
This is the first study to investigate the relationship between ceramides, the mitochondrial respiratory system, oxidative stress, inflammation, and apoptosis in the submandibular gland mitochondria of mice with insulin resistance (IR). The experiment was conducted on 20 male C57BL/6 mice
Hady Razak Hady et al.
Journal of clinical medicine, 8(12) (2019-12-18)
The liver plays a central role in the glucose and lipid metabolism. Studies performed on animal models have shown an important role of lipid accumulation in the induction of insulin resistance. We sought to explain whether in obese humans, the
Paul T Reidy et al.
The Journal of physiology, 596(21), 5217-5236 (2018-09-09)
Insulin sensitivity (as determined by a hyperinsulinaemic-euglyceamic clamp) decreased 15% after reduced activity. Despite not fully returning to baseline physical activity levels, insulin sensitivity unexpectedly, rebounded above that recorded before 2 weeks of reduced physical activity by 14% after the recovery

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