700051P
Avanti
22(S)-hydroxycholesterol-d7
Avanti Polar Lipids
Synonym(s):
25,26,26,26,27,27,27-heptadeuterocholest-5-ene-3β,22S-diol
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About This Item
Empirical Formula (Hill Notation):
C27H39O2D7
CAS Number:
Molecular Weight:
409.70
UNSPSC Code:
41141804
NACRES:
NA.25
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description
cholest-5-ene-3β,22(S)-diol-d7
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (700051P-1mg)
manufacturer/tradename
Avanti Polar Lipids
shipped in
dry ice
storage temp.
−20°C
General description
22(S)-hydroxycholesterol is an enantiomer of 22(R)-hydroxycholesterol. 22(S)-hydroxycholesterol-d7 is a deuterated form of 22(S)-hydroxycholesterol.
Application
22(S)-hydroxycholesterol-d7 may be used as an internal standard in liquid chromatography with tandem mass spectrometry (LC-MS-MS) analysis of plasma low-density lipoprotein (LDL).
Biochem/physiol Actions
22(S)-hydroxycholesterol (22(S)-HC) promotes glucose catabolism and uptake and is regarded as a potential target to treat type 2 diabetes. 22(S)-HC also prevents the accumulation of lipids and lipid synthesis in hepatocytes and myotubes. Unlike 22(R)-hydroxycholesterol, 22(S)-HC is not estrogenic and is not a ligand for liver X receptor (LXR).
Packaging
5 mL Amber Glass Screw Cap Vial (700051P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
Certificates of Analysis (COA)
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Hiroyoshi Sato et al.
Bioscience, biotechnology, and biochemistry, 68(8), 1790-1793 (2004-08-24)
In order to test the estrogenic activity of sterol oxidation products from cholesterol and phytosterols, an estrogen-dependent gene expression assay was performed in estrogen receptor alpha-stably transformed HeLa cells. The ranking of the estrogenic potency of these compounds was different:
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