SML3586
MU1700 dihydrochloride
≥98% (HPLC)
Synonym(s):
6-(4-(Piperazin-1-yl)phenyl)-3-(quinolin-4-yl)furo[3,2-b]pyridine dihydrochloride
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About This Item
Empirical Formula (Hill Notation):
C26H22N4O ·2HCl
Molecular Weight:
479.40
UNSPSC Code:
12352200
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
Biochem/physiol Actions
MU1700 is a potent and selective TGF-β type I receptors ALK1/ACVRL1 & ALK2/ACVR1 inhibitor (IC50 = 13/6 nM, [ATP] = 10 mM) that inhibits ALK6/BMPR1B only at higher concentrations (IC50 = 41 nM) with good kinome selectivity over >360 other kinases, including ALK3/BMPR1A (IC50 = 425 nM), ALK4/ACVR1B & ALK5/TGFBR1 (inactive). MU1700 inhibits cellular phospho-SMAD1/5/8 induction by 10 ng/mL BMP-7 and phospho-SMAD2 induction by either 10 ng/mL activin A or 100 ng/mL TGF-β1 with good target selectivity by cellular NanoBRET assays (ALK1/2 IC50 = 225/27 nM).
Caution
Hygroscopic
Certificates of Analysis (COA)
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