SML2347

RU.521

≥98% (HPLC)

• Synonym(s): 3-[1-(6,7-dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-pyrazol-4-yl]-3H-isobenzofuran-1-one, RU-521, RU320521
• Empirical Formula (Hill Notation): C₁₉H₁₂Cl₂N₄O₃
• CAS Number: 2262452-06-0
• Molecular Weight: 415.23
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: Clc1c2nc([nH]c2ccc1Cl)[n]3nc(c(c3O)C4OC(=O)c5c4cccc5)C
• InChI: 1S/C19H12Cl2N4O3/c1-8-13(16-9-4-2-3-5-10(9)18(27)28-16)17(26)25(24-8)19-22-12-7-6-11(20)14(21)15(12)23-19/h2-7,16,26H,1H3,(H,22,23)
• InChI key: VIQXILLOJLATEF-UHFFFAOYSA-N

Description

Biochem/physiol Actions

RU.521 (RU320521) is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS) that suppresses the chronically elevated levels of type I interferon in primary macrophages from Trex1 null mice. Ru.521 binds to the CGAS catalytic pocket and inhibits dsDNA-induced cGAS-mediated interferon upregulation.

RU.521 helps to understand the biological functions of cyclic guanosine monophosphate-adenosine monophosphate (cyclic GMP-AMP) synthase. It can act as a molecular scaffold for developing future autoimmune therapies. RU.521 can also inhibit the inflammatory cytokine expression induced by Aspergillus fumigatus.

potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS)

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable