SAB4502922

Anti-TAK1 antibody produced in rabbit

affinity isolated antibody

• Synonym(s): M3K7, MAP3K7, Mitogen-activated protein kinase kinase kinase 7, TGF-β- activated kinase 1, Transforming growth factor-β-activated kinase 1
• MDL number: MFCD02097469
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 67 kDa
• species reactivity: mouse, rat, human
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:1000; western blot: 1:500-1:1000
• NCBI accession no.: O43318
• UniProt accession no.: O43318
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... MAP3K7(6885)

Description

General description

Anti-TAK1 antibody detects endogenous levels of total TAK1 protein.

The TAK1 (Transforming growth factor β activated kinase 1) gene is mapped to human chromosome 6q15. It encodes for a mitogen-activated protein kinase 7 containing serine-threonine/tyrosine-protein kinase catalytic domain and a coiled-coil domain at the C-terminal.

Immunogen

The antiserum was produced against synthesized peptide derived from human TAK1.

Immunogen Range: 161-210

Biochem/physiol Actions

TAK1 (Transforming growth factor β (TGF-β) activated kinase 1) is activated by TGF-β and other inflammatory stimuli such as chemical and physical agents causing stress, cytokines, and microorganism moieties. TAK1 participates in mitogen-activated protein kinase (MAPK)-p38 signaling pathway. TAK1 is involved in the regulation of osteogenesis. TAK1 is important for productive autophagy.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable