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SAB4502615

Sigma-Aldrich

Anti-NF-κB p65 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

NFKB3, RELA, TF65, nuclear factor NF-κ-B p65 subunit, p65

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About This Item

MDL number:
MFCD00802848
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 60 kDa

species reactivity

human, rat, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

Q04206

UniProt accession no.

Q04206

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RELA(5970)

General description

Anti-NF-κB p65 Antibody detects endogenous levels of total NF-κB p65 protein.
RELA (v-rel avian reticuloendotheliosis viral oncogene homolog A), also known as nuclear factor κ-B (NF-κ-B) p65 subunit, codes for an important constituent of the NF-κB complex. The gene encoding it is localized on human chromosome 11q13.1. It is also referred as nuclear factor κB subunit 3 (NFκB3).

Immunogen

The antiserum was produced against synthesized peptide derived from human NF-kappaB p65.

Immunogen Range: 247-296

Application

Anti-NF-κB p65 antibody produced in rabbit is used in Western Blotting.

Biochem/physiol Actions

RELA (v-rel avian reticuloendotheliosis viral oncogene homolog A) or nuclear factor NF-κ-B p65 subunit participates in the nuclear factor κ-B (NFκB) signaling pathway. It also modulates inflammation. Alterations in the gene have been linked to schizophrenia and startle reactions.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Reversal of cardiac and skeletal manifestations of Duchenne muscular dystrophy by cardiosphere-derived cells and their exosomes in mdx dystrophic mice and in human Duchenne cardiomyocytes.
Aminzadeh MA, et al.
bioRxiv, 128900-128900 (2017)
Bone morphogenetic protein-2 exhibits therapeutic benefits for osteonecrosis of the femoral head through induction of cartilage and bone cells.
Wang C, et al.
Experimental and Therapeutic Medicine (2018)
Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci.
Pare G, et al.
PLoS Genetics, 7(4), e1001374-e1001374 (2011)
Variants of the RELA gene are associated with schizophrenia and their startle responses.
Hashimoto R, et al.
Neuropsychopharmacology, 36(9), 1921-1921 (2011)
Siwei Tan et al.
Cell death & disease, 12(5), 474-474 (2021-05-14)
Fas/Fas ligand (FasL)-mediated cell apoptosis involves a variety of physiological and pathological processes including chronic hepatic diseases, and hepatocytes apoptosis contributes to the development of liver fibrosis following various causes. However, the mechanism of the Fas/FasL signaling and hepatocytes apoptosis
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