L0517

Leukotriene B₄

~100 μg/mL in ethanol, ≥97%

• Synonym(s): [5S,12R]-Dihydroxy-[6Z,8E,10E,14Z]-eicosatetraenoic acid
• Empirical Formula (Hill Notation): C₂₀H₃₂O₄
• CAS Number: 71160-24-2
• Molecular Weight: 336.47
• EC Number: 200-578-6
• MDL number: MFCD00135630
• UNSPSC Code: 12352200
• PubChem Substance ID: 24896256
• NACRES: NA.77

Properties

• Quality Level: 200
• Assay: ≥97%
• form: liquid
• concentration: ~100 μg/mL in ethanol
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O
• InChI: 1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1
• InChI key: VNYSSYRCGWBHLG-AMOLWHMGSA-N
• Gene Information: human ... LTB4R(1241) ; rat ... Ltb4r(59264)

Description

Biochem/physiol Actions

Proinflammatory agent. Stimulates c-Fos and c-Jun proto-oncogene transcription in human monocytes. Stimulates chemotaxis, aggregation, and degranulation of polymorphonuclear leukocytes.

Features and Benefits

This compound is featured on the Leukotriene Receptors and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

Data sheet which accompanies each product includes special handling instructions. Except where noted, method for hydrolysis of methyl esters is also described.

Safety Information

• Pictograms: GHS02,GHS07
• Signal Word: Danger
• Hazard Statements: H225,H319
• Precautionary Statements: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): 57.2 °F - closed cup
• Flash Point(C): 14.0 °C - closed cup