I9783

Monoclonal Anti-Importin α3 antibody produced in rat

clone 3D10, purified immunoglobulin, buffered aqueous solution

• Synonym(s): Anti-Imp α
• MDL number: MFCD06798707
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rat
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 3D10, monoclonal
• form: buffered aqueous solution
• mol wt: antigen ~60 kDa
• species reactivity: mouse, hamster, bovine, canine, rat, human, monkey
• technique(s): microarray: suitable; western blot: 2-4 μg/mL using HeLa cell extract
• isotype: IgG2a
• UniProt accession no.: O00629
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... KPNA4(3840) ; mouse ... Kpna4(16649) ; rat ... Kpna4(361959)

Description

Immunogen

recombinant mouse importin α3/Qip1.

Biochem/physiol Actions

The gene KPNA4 (karyopherin subunit α 4) encodes a 16kDa protein, also referred to as importin α 3 belonging to the family of karyopherins (designated KPNA1 to KPNA4), that participates in the recognition of NLS (nuclear localization signal) sites and dock NLS-containing proteins destined for transport into the nuclear pore complex. It binds to translocon and participates in the sorting of INM (inner nuclear membrane)-directed integral membrane proteins. It associates with nucleoporins and functions in cargo-translocation across the nuclear membrane.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable