GW22757
Anti-AKT1 (ab1) antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
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About This Item
biological source
chicken
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, human, mouse
manufacturer/tradename
Genway 15-288-22757
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... AKT1(207)
Immunogen
Immunogen Sequence: GI # 62241011, sequence 2-200
Recombinant serine/threonine protein kinase
Application
Anti-AKT1 (ab1) antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
RAC-α serine/threonine-protein kinase is an enzyme encoded by the AKT1 gene in humans and is a member of the serine/threoine AGC protein kinase family. It is an intracellular signal transduction protein activated by growth hormones and its pathway is critically involved in cancer cell growth, proliferation, metabolism, invasion and survival. AKT1 acts as a potential target for cancer gene therapy. The gene is frequently activated in a variety of cancer types and is accepted as a promising anticancer therapeutic target.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Description
Pricing
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Min Zhang et al.
Clinical laboratory, 60(1), 1-8 (2014-03-08)
AKT1 is a member of the serine/threoine AGC protein kinase family involved in cancer's metabolism, growth, proliferation, and survival. It is a potential target for cancer gene therapy. In the present study, we used DNAzyme and siRNA technology to inhibit
F Yang et al.
Cell death & disease, 5, e1114-e1114 (2014-03-15)
The serine/threonine kinase AKT is generally accepted as a promising anticancer therapeutic target. However, the relief of feedback inhibition and enhancement of other survival pathways often attenuate the anticancer effects of AKT inhibitors. These compensatory mechanisms are very complicated and
Prognostic significance of protein kinase B/Akt pathway in patients with non-small cell lung cancer.
Alpaslan Mayadagli et al.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 19(1), 157-163 (2014-03-25)
Akt, also known as protein kinase B (PKB), is an intracellular signal transduction protein activated by growth hormones. PKB/Akt is frequently activated in a variety of cancer types, but its role in the development and progression of lung cancer has
Xiaoting Wang et al.
Journal of cancer research and clinical oncology, 140(8), 1399-1411 (2014-04-17)
v-akt Murine thymoma viral oncogene homolog (AKT) pathway is critically involved in cancer cell growth, invasion, and survival. We examined the correlation between the genetic variations in molecules of AKT pathway and clinical outcomes of gastric cancer. Six single nucleotide
Mariëtte E G Kranendonk et al.
Obesity (Silver Spring, Md.), 22(10), 2216-2223 (2014-07-22)
Insulin resistance (IR) is a key mechanism in obesity-induced cardiovascular disease. To unravel mechanisms whereby human adipose tissue (AT) contributes to systemic IR, the effect of human AT-extracellular vesicles (EVs) on insulin signaling in liver and muscle cells was determined.
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