G7504
Guanosine 3′,5′-cyclic monophosphate
≥98% (HPLC), powder, intracellular mediator
Synonym(s):
cGMP, cyclic GMP
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About This Item
Empirical Formula (Hill Notation):
C10H12N5O7P
CAS Number:
Molecular Weight:
345.21
EC Number:
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.77
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Product Name
Guanosine 3′,5′-cyclic monophosphate, ≥98% (HPLC), powder
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white
solubility
0.2 M NaHCO3: 50 mg/mL
storage temp.
−20°C
SMILES string
NC1=NC(=O)c2ncn(C3OC4COP(O)(=O)OC4C3O)c2N1
InChI
1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)
InChI key
ZOOGRGPOEVQQDX-UHFFFAOYSA-N
Biochem/physiol Actions
An important second messenger, cGMP is a major intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides. Cyclic GMP interacts with three types of intracellular receptor proteins: cGMP-dependent protein kinases, cGMP-regulated channels, and cGMP-regulated cyclic nucleotide phosphodiesterases. A primary action of elevated cGMP levels in vivo is the stimulation of cGMP-dependent protein kinase (PKG).
Features and Benefits
This compound is a featured product for ADME Tox and Cyclic Nucleotide research. Discover more featured ADME Tox and Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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