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E0643

Sigma-Aldrich

Erythropoietin Soluble Receptor Peptide

>90% (SDS-PAGE), lyophilized powder, human recombinant, expressed in NSO cells

Synonym(s):

EPO sR

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About This Item

MDL number:
MFCD01323248
UNSPSC Code:
51111800
NACRES:
NA.32

product name

Erythropoietin Soluble Receptor human, >90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

biological source

human

Quality Level

200

recombinant

expressed in NSO cells

Assay

>90% (SDS-PAGE)

form

lyophilized powder

potency

74 ng/mL

mol wt

~25 kDa

packaging

pkg of 50 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

UniProt accession no.

P19235

storage temp.

−20°C

Gene Information

human ... EPOR(2057)

Biochem/physiol Actions

Recombinant human soluble erythropoietin receptor binds erthropoietin with high affinity and is an erythropoietin antagonist.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5% trehalose and 50 ug of bovine serum albumin per 1 ug of cytokine.

Analysis Note

The biological activity is measured by its ability to inhibit the recombinant human erythropoietin mediated cell proliferation of human TF1 cells.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Soluble Erythropoietin Receptor Contributes To Erythropoietin Resistance In End-stage Renal Disease.
Khankin, E.V., et al.
PLoS Biology, 5, e9246-e9246 (2010)
T Kitamura et al.
Journal of cellular physiology, 140(2), 323-334 (1989-08-01)
We have established a novel cell line, designated as TF-1, from a patient with erythroleukemia, which showed complete growth dependency on granulocyte-macrophage colony-stimulating factor (GM-CSF) or on interleukin-3 (IL-3) and carried a homogeneous chromosomal abnormality (54X). Erythropoietin (EPO) also sustained

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