70485
Naphthol AS-E phosphate
suitable for histology
Synonym(s):
KG-501
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About This Item
Empirical Formula (Hill Notation):
C17H13ClNO5P
CAS Number:
Molecular Weight:
377.72
Beilstein:
6664478
EC Number:
MDL number:
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.83
Recommended Products
Assay
≥80% (HPLC)
form
powder
application(s)
histology
storage temp.
2-8°C
SMILES string
OP(O)(=O)Oc1cc2ccccc2cc1C(=O)Nc3ccc(Cl)cc3
InChI
1S/C17H13ClNO5P/c18-13-5-7-14(8-6-13)19-17(20)15-9-11-3-1-2-4-12(11)10-16(15)24-25(21,22)23/h1-10H,(H,19,20)(H2,21,22,23)
InChI key
RQAQWBFHPMSXKR-UHFFFAOYSA-N
Related Categories
Application
Naphthol AS-E phosphate has been used as a cAMP-response element-binding protein (CREB) inhibitor to dissolve in dimethyl sulfoxide (DMSO) as a stock solution in the study to test the hypothesis that oncostatin M (OSM) may confer neuronal resistance against 3-nitropropionic acid (3-NP).
Biochem/physiol Actions
Naphthol AS-E phosphate/KG501, a small-molecule antagonist has the ability to prevent cAMP-response element-binding protein (CREB) pathway. It can also interfere with the interaction of Myb-KIX in vitro and block the actions of Myb in vivo.
Other Notes
Histochemical substrate for alkaline phosphatases,KG-501 blocks cAMP-induction of CREB (cAMP Response Element Binding Protein)-dependent target gene transcription (Ki 10 microM)) through interference in the binding between the KID domain of CREB and KIX domain of CBP (CREB Binding Protein), classic activator-coactivator interaction.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Naphthol AS-E phosphate inhibits the activity of the transcription factor Myb by blocking the interaction with the KIX domain of the coactivator p300
Uttarkar S, et al.
Molecular Cancer Therapeutics, molcanther-molcan0662 (2015)
Phosphates of the naphthol AS series in the quantitative determination of alkaline and acid phosphatase activities in situ studied in polyacrylamide membrane model systems and by cytospectrophotometry
Lojda, Z., et al.
Histochemistry and Cell Biology, 11, 13-32 (1967)
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PloS one, 6(11), e28280-e28280 (2011-12-06)
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