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314R-1

Sigma-Aldrich

Cytokeratin 14 (SP53) Rabbit Monoclonal Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

SP53, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (314R-14)
vial of 0.5 mL concentrate (314R-15)
bottle of 1.0 mL predilute (314R-17)
vial of 1.0 mL concentrate (314R-16)
bottle of 7.0 mL predilute (314R-18)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG

control

squamous carcinoma

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... KRT14(3861)

Related Categories

General description

Cytokeratin 14 is a 50 kDa polypeptide found in basal cells of squamous epithelia, some glandular epithelia, myoepithelium, and mesothelial cells. Anti-CK14 is expressed in most squamous cell carcinomas, in epithelioid mesothelioma, and in the basal-like phenotype of breast carcinoma.
Anti-CK14 has been demonstrated to be useful in differentiating squamous cell carcinomas from other epithelial tumors. This antibody has also been useful in separating oncocytic tumors of the kidney from its renal mimics, as well as in identifying metaplastic carcinomas of the breast. Anti-CK14 is particularly valuable in identifying basal-like carcinoma of the breast.

Quality


IVD
IVD
IVD
RUO

Linkage

Cytokeratin 14 Positive Control Slides, Product No. 314S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Certificates of Analysis (COA)

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Diagnostic Immunohistochemistry: Theranostic and Genomic Applications, 166-176 (2002)
P G Chu et al.
Histopathology, 39(1), 9-16 (2001-07-17)
The tissue distribution of cytokeratin 14 (CK14) in epithelial neoplasms is not well defined. We have evaluated 435 cases of epithelial neoplasm of various origins with cytokeratin 14 monoclonal antibody with special attention to possible use in differential diagnosis. Immunohistochemistry
Jorge S Reis-Filho et al.
Applied immunohistochemistry & molecular morphology : AIMM, 11(1), 1-8 (2003-03-01)
Metaplastic carcinomas of the breast (MCBs) are unusual neoplasms characterized by an admixture of glandular epithelial components, which frequently exhibit features of squamous differentiation, and mesenchymal malignant components. Regardless of the presence of myoepithelial features in MCB, no consensus concerning
P G Chu et al.
Histopathology, 39(5), 455-462 (2001-12-12)
The cytokeratin 14 (CK14) expression in oncocytomas or oncocytic tumours of various tissue origins has not been established. We have studied CK14 expression in 30 cases of oncocytic tumours of various tissue origins and 33 cases of renal cell carcinoma

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