BP016

Amitriptyline hydrochloride

British Pharmacopoeia (BP) Reference Standard

• Empirical Formula (Hill Notation): C₂₀H₂₃N · HCl
• CAS Number: 549-18-8
• Molecular Weight: 313.86
• MDL number: MFCD00012537
• UNSPSC Code: 12352200
• NACRES: NA.24

Properties

• grade: pharmaceutical primary standard
• API family: amitriptyline
• form: powder
• shelf life: limited shelf life, expiry date on the label
• manufacturer/tradename: BP
• application(s): pharmaceutical
• format: neat
• storage temp.: 2-8°C
• SMILES string: Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13
• InChI: 1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H
• InChI key: KFYRPLNVJVHZGT-UHFFFAOYSA-N
• Gene Information: human ... SLC6A2(6530) , SLC6A4(6532)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Amitriptyline hydrochloride BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:

Amitriptyline Oral Solution

Amitriptyline Tablets

Biochem/physiol Actions

Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with K_is of 100 nM and 14.7 nM, respectively; high in vitro affinity for α₁-adrenoceptors, serotonin and muscarinic acetylcholine receptors.

Packaging

Unit quantity: 150 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

Other Notes

Sales restrictions may apply.

Safety Information

• Pictograms: GHS06,GHS08,GHS09
• Signal Word: Danger
• Hazard Statements: H301 - H319 - H361d - H410
• Precautionary Statements: P202 - P264 - P273 - P280 - P301 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable