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MAB3662

Sigma-Aldrich

Anti-TIF1 beta Antibody

ascites fluid, Chemicon®

Synonym(s):

TIF1beta

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

ascites fluid

antibody product type

primary antibodies

clone

monoclonal

species reactivity

mouse, human

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
immunocytochemistry: suitable
western blot: suitable

isotype

IgG2b

NCBI accession no.

NM_005762.2

UniProt accession no.

Q13263

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... TRIM28(10155)

Specificity

Recognizes transcriptional intermediary factor 1beta (TIF1beta). The epitope is localized between amino acids 123-834 of mouse TIF1beta. No cross reactivity with TIF1alpha.

Immunogen

Recombinant protein from mouse TIF1b.

Application

Anti-TIF1 beta Antibody is a Mouse Monoclonal Antibody for detection of Transcriptional Intermediary Factor 1 also known as TIF1 beta & has been validated in ELISA, WB, ICC.
Western blot: 1:500-1:5,000

Immunocytochemistry: 1:500-1:5,000

ELISA: 1:500-1:5,000

Optimal working dilutions must be determined by the end user.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Trim28, cause increased phenotypic noise.
Whitelaw, NC; Chong, S; Morgan, DK; Nestor, C; Bruxner, TJ; Ashe, A; Lambley, E; Meehan et al.
Genome Biology null
Florence Cammas et al.
Journal of cell science, 115(Pt 17), 3439-3448 (2002-08-03)
The transcriptional intermediary factor 1 (TIF1) family protein TIF1beta is a corepressor for Krüppel-associated box (KRAB)-domain-containing zinc finger proteins and plays a critical role in early embryogenesis. Here, we examined TIF1beta distribution in the nucleus of mouse embryonic carcinoma F9
A L Nielsen et al.
The EMBO journal, 18(22), 6385-6395 (1999-11-24)
Mammalian TIF1alpha and TIF1beta (KAP-1/KRIP-1) are related transcriptional intermediary factors that possess intrinsic silencing activity. TIF1alpha is believed to be a euchromatic target for liganded nuclear receptors, while TIF1beta may serve as a co-repressor for the large family of KRAB
KAP1 controls endogenous retroviruses in embryonic stem cells.
Helen M Rowe,Johan Jakobsson,Daniel Mesnard,Jacques Rougemont,Severine Reynard et al.
Nature null
Andrea Coluccio et al.
Epigenetics & chromatin, 11(1), 7-7 (2018-02-28)
The KZFP/KAP1 (KRAB zinc finger proteins/KRAB-associated protein 1) system plays a central role in repressing transposable elements (TEs) and maintaining parent-of-origin DNA methylation at imprinting control regions (ICRs) during the wave of genome-wide reprogramming that precedes implantation. In naïve murine
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