217694

Cdc25 Inhibitor IV, NSC 95397

The Cdc25 Inhibitor IV, NSC 95397, also referenced under CAS 93718-83-3, controls the biological activity of Cdc25. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(s): Cdc25 Inhibitor IV, NSC 95397, (2,3-bis-[2-hydroxyethylsulfanyl]-[1,4]naphthoquinone), PTP Inhibitor XXIX
• Empirical Formula (Hill Notation): C₁₄H₁₄O₄S₂
• CAS Number: 93718-83-3
• Molecular Weight: 310.39
• MDL number: MFCD04040032
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: orange
• solubility: DMSO: 100 mg/mL, clear, red
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: O=C1C(SCCO)=C(SCCO)C(C2=CC=CC=C21)=O
• InChI: 1S/C14H14O4S2/c15-5-7-19-13-11(17)9-3-1-2-4-10(9)12(18)14(13)20-8-6-16/h1-4,15-16H,5-8H2
• InChI key: MAASHDQFQDDECQ-UHFFFAOYSA-N

Description

General description

A cell-permeable, para-naphthoquinone that has been reported to inhibit protein tyrosine phosphatase activity, including Cdc25 dual specificity phosphatase (K_i = 32 nM, 96 nM, and 40 nM for Cdc25A, -B, and -C, respectively) and blocks G₂M transition in murine carcinoma cells. In addition, it is shown to inhibit S100A4 binding to myosin-IIA via covalent modification of cysteine residues, Cys81 and Cys86, in the target binding cleft (IC₅₀ = 1.8 µM). It demonstrates inhibitory activity against S100A4-mediated depolymerization of myosin-IIA filaments.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Dulyaninova, N.G., et al. 2011. Biochemistry50, 7218.
Lazo, J.S., et al. 2002. Mol. Pharmacol.61, 720.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable