1.00264

Formic acid 98-100%

for analysis EMSURE^® ACS,Reag. Ph Eur

• Synonym(s): Formic acid, Methanoic acid, Formylic acid
• Linear Formula: HCOOH
• CAS Number: 64-18-6
• Molecular Weight: 46.03
• Beilstein: 1209246
• MDL number: MFCD00003297
• UNSPSC Code: 12352106
• EC Index Number: 200-579-1

Properties

• grade: ACS reagent
• Quality Level: 300
• Agency: reag. Ph. Eur.
• vapor density: 1.6 (vs air)
• vapor pressure: 44.8 mmHg ( 20 °C)
• product line: EMSURE^®
• Assay: ≥98% (alkalimetric)
• form: liquid
• autoignition temp.: 1004 °F
• expl. lim.: 12-38 % (v/v); 57 %
• technique(s): HPLC: suitable
• impurities: ≤500 ppm Acetic acid (CH₃COOH)
• evapn. residue: ≤10 ppm
• color: APHA: ≤10
• refractive index: n20/D 1.370 (lit.)
• pH: 2.2 (20 °C, 10 g/L in H₂O)
• bp: 100-101 °C (lit.); 101 °C/1013 hPa
• mp: 8.2-8.4 °C (lit.)
• transition temp: flash point 49.5 °C
• density: 1.22 g/mL at 25 °C (lit.)
• anion traces: chloride (Cl^-): ≤5 ppm; sulfate (SO₄^2-): ≤5 ppm; sulfite (SO₃^2-): ≤10 ppm
• cation traces: Ag: ≤0.020 ppm; Al: ≤0.050 ppm; Ba: ≤0.050 ppm; Be: ≤0.020 ppm; Bi: ≤0.10 ppm; Ca: ≤0.20 ppm; Cd: ≤0.050 ppm; Co: ≤0.020 ppm; Cr: ≤0.050 ppm; Cu: ≤0.020 ppm; Fe: ≤2.0 ppm; Ge: ≤0.050 ppm; K: ≤0.10 ppm; Li: ≤0.020 ppm; Mg: ≤0.50 ppm; Mn: ≤0.050 ppm; Mo: ≤0.020 ppm; NH₄⁺: ≤10 ppm; Na: ≤0.50 ppm; Ni: ≤0.050 ppm; Pb: ≤0.020 ppm; Sr: ≤0.020 ppm; Ti: ≤0.10 ppm; Tl: ≤0.050 ppm; V: ≤0.050 ppm; Zn: ≤0.050 ppm; Zr: ≤0.10 ppm; heavy metals (as Pb): ≤10 ppm
• SMILES string: OC=O
• storage temp.: 15-25°C
• InChI: 1S/CH2O2/c2-1-3/h1H,(H,2,3)
• InChI key: BDAGIHXWWSANSR-UHFFFAOYSA-N

Description

General description

for analysis EMSURE^® ACS,Reag. Ph Eur

Application

• Modified QuEChERS method combined with ultra performance liquid chromatography-tandem mass spectrometry for detection of cyclopiazonic acid in feeds: This study demonstrates the use of 98-100% formic acid in a modified QuEChERS method, enhancing the efficiency of toxin detection in animal feeds, crucial for maintaining food safety and environmental health (Peng et al., 2024).


• Adapting Fabric Phase Sorptive Extraction as an Innovative Multitool for Sample Transfer and Extraction in Pharmacokinetic Analysis Followed by LC-MS Determination of Levofloxacin in Plasma Samples: This study utilizes formic acid in developing advanced extraction methods for pharmacokinetic analysis, critical for drug development and therapeutic monitoring in pharmaceutical research (Ekin Dolaksız et al., 2024).


• Stability Indicating Method Development and Validation of Glycyrrhizin Using RP-HPLC-DAD: Application to Glycyrrhiza glabra Extract: This research uses formic acid in chromatographic analyses to ensure the stability and quality of herbal medicine compounds, relevant in both pharmaceutical and biotechnological fields (Lyngdoh et al., 2024).

Analysis Note

Assay (alkalimetric)≥ 98.0 %Color≤ 10 HazenAcetic acid (CH₃COOH)≤ 500 ppmChloride (Cl)≤ 5 ppmSulfate (SO₄)≤ 5 ppmSulfite (SO₃)≤ 10 ppmHeavy metals (as Pb)≤ 10 ppmAg (Silver)≤ 0.020 ppmAl (Aluminium)≤ 0.050 ppmBa (Barium)≤ 0.050 ppmBe (Beryllium)≤ 0.020 ppmBi (Bismuth)≤ 0.10 ppmCa (Calcium)≤ 0.20 ppmCd (Cadmium)≤ 0.050 ppmCo (Cobalt)≤ 0.020 ppmCr (Chromium)≤ 0.050 ppmCu (Copper)≤ 0.020 ppmFe (Iron)≤ 2.0 ppmGe (Germanium)≤ 0.050 ppmK (Potassium)≤ 0.10 ppmLi (Lithium)≤ 0.020 ppmMg (Magnesium)≤ 0.50 ppmMn (Manganese)≤ 0.050 ppmMo (Molybdenum)≤ 0.020 ppmNH₄ (Ammonium)≤ 10 ppmNa (Sodium)≤ 0.50 ppmNi (Nickel)≤ 0.050 ppmPb (Lead)≤ 0.020 ppmSr (Strontium)≤ 0.020 ppmTi (Titanium)≤ 0.10 ppmTl (Thallium)≤ 0.050 ppmV (Vanadium)≤ 0.050 ppmZn (Zinc)≤ 0.050 ppmZr (Zirconium)≤ 0.10 ppmEvaporation residue≤ 10 ppmDilution testpasses testACS, Ph Eur-Reagent
Expiry date : see product label

Legal Information

EMSURE is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS05,GHS06
• Signal Word: Danger
• Hazard Statements: H226 - H302 - H314 - H331
• Precautionary Statements: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1A
• Supplementary Hazards: EUH071
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): 121.1 °F - closed cup
• Flash Point(C): 49.5 °C - closed cup