O-006

Oxycodone-D₃ solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Empirical Formula (Hill Notation): C₁₈H₁₈NO₄D₃
• CAS Number: 160227-46-3
• Molecular Weight: 318.38
• EC Number: 200-659-6
• MDL number: MFCD28038719
• UNSPSC Code: 41116107
• PubChem Substance ID: 329818815
• NACRES: NA.24

Properties

• grade: certified reference material
• Quality Level: 300
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• drug control: Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)
• concentration: 1.0 mg/mL in methanol
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): forensics and toxicology
• format: single component solution
• storage temp.: −20°C
• SMILES string: O[C@]1([C@H](N(C)CC2)C3)[C@@]42C5=C3C=CC(OC([2H])([2H])[2H])=C5O[C@H]4C(CC1)=O
• InChI: 1S/C18H21NO4/c1-19-8-7-17-14-10-3-4-12(22-2)15(14)23-16(17)11(20)5-6-18(17,21)13(19)9-10/h3-4,13,16,21H,5-9H2,1-2H3/t13-,16+,17+,18-/m1/s1/i2D3
• InChI key: BRUQQQPBMZOVGD-CLILCLBHSA-N

Description

General description

This internal standard is suited for quantification of oxycodone levels in urine, serum, or plasma by LC/MS or GC/MS for urine drug testing, clinical toxicology, forensic analysis, or isotope dilution methods. Oxycodone is a semi-synthetic opioid analgesic sold under many trade names including OxyContin^® and Percocet^® for treatment of moderate to severe pain. Oxycodone is also sold illicitly under street names such as "Roxies," "Blues," and "Perks".

Application

• Pharmacokinetic Analysis: Lu et al. used Oxycodone-D3 in a study to develop a method for the simultaneous determination of acetaminophen and oxycoDonein human plasma, highlighting its utility in pharmacokinetic analysis and as an internal standard in LC-MS/MS assays (Lu et al., 2018).
• Bioanalytical Method Validation: Bergeron et al. discussed the importance of using high-purity internal standards like Oxycodone-D3 for successful bioanalytical assays, emphasizing its role in improving the accuracy and reliability of liquid chromatography/tandem mass spectrometric analyses (Bergeron et al., 2009).
• Postmortem Distribution: Anderson et al. explored the postmortem tissue distribution of oxycodone, using Oxycodone-D3 to trace its levels in various tissues, which is crucial for forensic toxicology and understanding the drug′s behavior in the human body after death (Anderson et al., 2002).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

OxyContin is a registered trademark of Purdue Pharma L.P.

Percocet is a registered trademark of Endo Pharmaceuticals Inc.

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H225 - H301 + H311 + H331 - H370
• Precautionary Statements: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 49.5 °F - closed cup
• Flash Point(C): 9.7 °C - closed cup