700094P
Avanti
cholestanol-d5
Avanti Research™ - A Croda Brand
Synonym(s):
111020
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About This Item
Empirical Formula (Hill Notation):
C27H43D5O
CAS Number:
Molecular Weight:
393.70
UNSPSC Code:
12352211
NACRES:
NA.25
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description
2,2,3,4,4-pentadeuterio-5α-cholestan-3β-ol
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (700094P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
General description
Cholestanol-d5 is a deuterated form of cholestanol. Cholestanol is a plant saturated sterol and has Δ5 double bond to the 5α position in the cholesterol structure and is a 5α-dihydro derivative of cholesterol.
Biochem/physiol Actions
Cholestanol deuterated has been administered in small intestine samples for the quantification of sterols by gas chromatography-mass spectrometry. The levels of cholesterol and cholestanol are elevated in tendons and brain in cerebrotendinous xanthomatosis due to the CYP27A1 (Cytochrome P450 Family 27 Subfamily A Member 1) deficiency. Cholestanol-d5 is useful as an internal standard to spike sediment samples for tandem mass spectrometry (MS/MS) for fecal sterol quantification. Cholestanol is a cholesterol absorption biomarker.
Packaging
5 mL Amber Glass Screw Cap Vial (700094P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
Certificates of Analysis (COA)
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Microbial water quality and sedimentary faecal sterols as markers of sewage contamination in Kuwait.
B P Lyons et al.
Marine pollution bulletin, 100(2), 689-698 (2015-08-01)
Microbial water quality and concentrations of faecal sterols in sediment have been used to assess the degree of sewage contamination in Kuwait's marine environment. A review of microbial (faecal coliform, faecal streptococci and Escherichia coli) water quality data identified temporal
Ann Båvner et al.
Journal of lipid research, 51(9), 2722-2730 (2010-06-01)
The rare disease cerebrotendinous xanthomatosis (CTX) is due to a lack of sterol 27-hydroxylase (CYP27A1) and is characterized by cholestanol-containing xanthomas in brain and tendons. Mice with the same defect do not develop xanthomas. The driving force in the development
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