927317
Linear polyethylenimine-block-poly(ethylene glycol)
PEG average Mn 750, PEI average Mn 15,000
Synonym(s):
PEG-b-PEI, PEG-PEI, poly(ethylene glycol)-block-polyethylenimine
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About This Item
Linear Formula:
CH3(C2H4O)n(C2H5N)mOH
UNSPSC Code:
12162002
NACRES:
NA.21
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form
solid
Quality Level
mol wt
PEG Mn 750 Da
PEG average Mn 750
PEI Mn 15,000 Da
PEI average Mn 15,000
color
white to yellow
storage temp.
2-8°C
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Application
Due to their low immunogenicity profiles, polymeric nonviral vectors have shown promise in advancing the treatment of many severe genetic and acquired diseases via gene therapy. Poly(ethyleneimine) is one of the most commonly used cationic polymers for gene delivery applications. Copolymers of PEI and hydrophilic poly(ethylene glycol) have been designed to provide a stealth-like shield around polymer/DNA complexes, reducing nonspecific interactions, inhibiting activation of the reticuloendothelial system, and prolonging the half-life of the complexes in the blood.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Pallab Banerjee et al.
Bioconjugate chemistry, 17(1), 125-131 (2006-01-19)
A block copolymer of a hyperbranched poly(ethylene glycol)-like core and linear polyethylenimine (HBP) was synthesized by a facile synthetic route that included (1) a single-step cationic copolymerization of diepoxy and polyhydroxyl monomers, (2) derivatization of hydroxyl groups of the core
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