920908
(S,R,S)-VL285 Phenol
Synonym(s):
(2S,4R)-4-Hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamide, VHL E3 ligase ligand for PROTAC® research
About This Item
Recommended Products
ligand
VL285 phenol
Quality Level
form
solid
reaction suitability
reagent type: ligand
functional group
amine
storage temp.
2-8°C
SMILES string
O=C([C@@H]1C[C@@H](O)CN1C([C@H](C(C)C)N2CC(C=CC=C3)=C3C2=O)=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4O
Related Categories
Application
(S,R,S)-VL285 Phenol-linker conjugates are also available for synthesis of degraders. Browse our full offering of degrader building blocks that streamlines the synthesis of degrader libraries.
Other Notes
Portal: Building PROTAC® Degraders for Targeted Protein Degradation
HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins
Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders
Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties
Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase
Legal Information
related product
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Articles
Protein Degrader Building Blocks are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.
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