911798

N-(4-Bromophenyl)-N-phenylacrylamide

≥95%

• Synonym(s): Electrophilic scout fragment, KB05, Scout fragment for targetable cysteine
• Empirical Formula (Hill Notation): C₁₅H₁₂BrNO
• CAS Number: 1956368-15-2
• Molecular Weight: 302.17
• UNSPSC Code: 12352200
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: ≥95%
• form: (Powder or crystals or solid or chunks)
• storage temp.: 2-8°C

Description

Application

N-(4-Bromophenyl)-N-phenylacrylamide is a cysteine-reactive small-molecule fragment for chemoproteomic and ligandability studies for both traditionally druggable proteins as well as ″undruggable,″ or difficult-to-target, proteins. This fragment electrophile, or ″scout″ fragment, can be used alone in fragment-based covalent ligand discovery or incorporated into bifunctional tools such as electrophilic PROTAC^® molecules for targeted protein degradation as demonstrated by the Cravatt Lab for E3 ligase discovery.

Other Notes

Technology Spotlight: Proteomic Ligandability Assessment

Proteome-wide covalent ligand discovery in native biological systems

Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3