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Key Documents

901573

Sigma-Aldrich

Bromo-PEG1-acid

≥95%

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About This Item

Empirical Formula (Hill Notation):
C5H9BrO3
CAS Number:
Molecular Weight:
197.03
MDL number:
UNSPSC Code:
12352101

Assay

≥95%

form

powder, crystals or chunks

reaction suitability

reagent type: linker

functional group

bromo
carboxylic acid

storage temp.

−20°C

SMILES string

BrCCOCCC(O)=O

Application

Bromo-PEG1-acid is a heterobifunctional, PEGylated crosslinker featuring a bromo group at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. Bromo-PEG1-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.
This is a crosslinker with a bromo group on one end and a carboxyl group on the other end. The compound contains a single PEG unit to help improve solubility.

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

related product

Product No.
Description
Pricing

Storage Class Code

10 - Combustible liquids

WGK

WGK 3


Certificates of Analysis (COA)

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