SML3091
Irresistin-16
≥98% (HPLC)
Synonym(s):
7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine,7-([1,1?-biphenyl]-4-ylmethyl), IRS-16
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About This Item
Empirical Formula (Hill Notation):
C23H19N5
CAS Number:
Molecular Weight:
365.43
UNSPSC Code:
51111800
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
NC1=NC(N)=NC2=C1C3=C(C=C2)N(CC4=CC=C(C=C4)C5=CC=CC=C5)C=C3
Biochem/physiol Actions
Irresistin-16, an SCH 79797 derivative, is a broad spectrum bactericidal antibiotic that is effective in both gram-positive and gram-negative bacteria and exhibits low frequency of resistance. Irresistin-16 act through interruption of bacterial folate metabolism and bacterial membrane integrity. It inhibits E. coli dihydrofolate reductase FolA. Irresistin-16 is effective in mouse gonorrhea infection model.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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James K Martin et al.
Cell, 181(7), 1518-1532 (2020-06-05)
The rise of antibiotic resistance and declining discovery of new antibiotics has created a global health crisis. Of particular concern, no new antibiotic classes have been approved for treating Gram-negative pathogens in decades. Here, we characterize a compound, SCH-79797, that
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