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SML1169

Sigma-Aldrich

Pitstop 2

≥98% (HPLC), powder, clathrin-mediated endocytosis inhibitor

Synonym(s):

N-[5-[(4-Bromophenyl)methylene]-4,5-dihydro-4-oxo-2-thiazolyl]-1-naphthalenesulfonamide, Pitstop-2

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About This Item

Empirical Formula (Hill Notation):
C20H13BrN2O3S2
CAS Number:
Molecular Weight:
473.36
UNSPSC Code:
12352200
NACRES:
NA.77

product name

Pitstop 2, ≥98% (HPLC)

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to light brown

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

Application

Pitstop 2 has been used as an inhibitor of clathrin-mediated endocytosis.

Biochem/physiol Actions

Pitstop 2 also has an ability to breakdown the nuclear pore complex (NPC) permeability barrier and decrease importin β binding along with alteration of the NPC ultrastructure. Pitstop 2 is also involved in the inhibition of platelet activation, platelet aggregation and secretion.
Pitstop 2 is a selective inhibitor of clathrin-mediated endocytosis that acts via blocking ligand access to the clathrin terminal domain. Pitstop 2 selectively inhibits clathrin-mediated HIV entry and stalls clathrin-coated pit (CCP) dynamics.
Pitstop 2 is a selective inhibitor of clathrin-mediated endocytosis.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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