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Key Documents

SAB4300024

Sigma-Aldrich

Anti-phospho-MYC (pThr58) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-bHLHe39 antibody produced in rabbit, Anti-c-Myc antibody produced in rabbit, Anti-v-myc myelocytomatosis viral oncogene homolog (avian) antibody produced in rabbit

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
conjugate:
unconjugated
application:
IHC (p)
WB
clone:
polyclonal
species reactivity:
human, mouse, rat
citations:
2
technique(s):
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~60 kDa

species reactivity

human, mouse, rat

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(L-P-TP-P-P)

NCBI accession no.

NP_002458.2

UniProt accession no.

P01106

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pThr58)

Gene Information

human ... MYC(4609)

Immunogen

Peptide sequence around phosphorylation site of threonine 58 (L-P-T(p)-P-P), according to the protein MYC.

Features and Benefits

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Target description

Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
511711034

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V H Cowling et al.
Oncogene, 33(27), 3519-3527 (2013-09-10)
Burkitt's lymphomas (BLs) acquire consistent point mutations in a conserved domain of Myc, Myc Box I. We report that the enhanced transforming activity of BL-associated Myc mutants can be uncoupled from loss of phosphorylation and increased protein stability. Furthermore, two
Hideki Izumi et al.
Cancer research, 74(19), 5620-5630 (2014-08-08)
Asymmetric cell division (ACD) is a physiologic process during development and tissue homeostasis. ACD produces two unequal daughter cells: one has stem/progenitor cell activity and the other has potential for differentiation. Recent studies showed that misregulation of the balance between

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