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SAB2500965

Sigma-Aldrich

Anti-SNAP25 antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-FLJ23079, Anti-HGNC:11132, Anti-SNAP, Anti-Synaptosomal-associated protein

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About This Item

MDL number:
MFCD00675279
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, canine, human, mouse

technique(s)

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

P60880

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SNAP25(6616)

General description

Synaptosome associated protein 25 (SNAP25) is a component of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex. It is expressed in pancreatic endocrine cells. The gene encoding this protein is localized on human chromosome 20p12.2.

Immunogen

Peptide with sequence C-DEANQRATKMLGSG from the C Terminus of the protein sequence according to NP_003072.2; NP_570824.1.

Biochem/physiol Actions

Synaptosome associated protein 25 (SNAP25) has a role in vesicle mobilization, exocytosis and may have a role in fusion of synaptic vesicles. It is involved in modulating the activity of potassium voltage gated (Kv) 2.1 channels. SNAP25 has been associated with attention-deficit/hyperactivity disorder (ADHD).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Synaptosome-Associated Protein 25 (SNAP25) Gene Association Analysis Revealed Risk Variants for ASD, in Iranian Population.
Safari MR
Journal of Molecular Neuroscience (2017)
SNAP25 is associated with schizophrenia and major depressive disorder in the Han Chinese population.
Wang Q
The Journal of Clinical Psychiatry (2015)
Detection of lower levels of SNAP25 using multiple microarray systems and its functional significance in medulloblastoma.
Huang CJ
International Journal of Molecular Medicine (2017)
Synaptosomal Protein of 25 kDa (Snap25) Polymorphisms Associated with Glycemic Parameters in Type 2 Diabetes Patients.
Al-Daghri
Journal of Diabetes Research (2016)
Masanori Itakura et al.
Biochemical and biophysical research communications, 447(2), 311-314 (2014-04-10)
Recent reports indicate that interruption of acetylcholine release by intrastriatal injection of botulinum neurotoxin type A (BoNT/A) in a rat Parkinson's disease model reduces pathogenic behavior without adverse side effects such as memory dysfunction. Current knowledge suggests that BoNT/A subtype

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