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P4747

Sigma-Aldrich

Anti-Potassium Channel KCa2.3, (C-term) (Small-conductance Ca2+-activated Potassium Channel 3) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-SK3, Anti-SKCa3

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About This Item

MDL number:
MFCD06798512
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human, mouse, rat, pig

technique(s)

western blot: 1:200 using rat brain membranes

UniProt accession no.

Q9UGI6

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... KCNN3(3782)
mouse ... Kcnn3(140493)
rat ... Kcnn3(54263)

Immunogen

Synthetic peptide corresponding to amino acid residues 659-674 of human KCa2.3. This sequence has 100% homology in rat, mouse, pig.

Physical form

Lyophilized powder from phosphate buffered saline containing 1% bovine serum albumin and 0.05% sodium azide.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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H Tomita et al.
Molecular psychiatry, 8(5), 524-535 (2003-06-17)
The small-conductance calcium-activated K(+) channel SK3 (SKCa3/KCNN3) regulates electrical excitability and neurotransmitter release in monoaminergic neurons, and has been implicated in schizophrenia, ataxia and anorexia nervosa. We have identified a novel SK3 transcript, SK3-1B that utilizes an alternative first exon
C Vergara et al.
Current opinion in neurobiology, 8(3), 321-329 (1998-08-04)
Calcium-activated potassium channels are fundamental regulators of neuronal excitability, participating in interspike interval and spike-frequency adaptation. For large-conductance calcium-activated potassium (BK) channels, recent experiments have illuminated the fundamental biophysical mechanisms of gating, demonstrating that BK channels are voltage gated and
Shaun L Sandow et al.
Journal of anatomy, 209(5), 689-698 (2006-10-26)
Activation of endothelial cell small- (S) and intermediate- (I) conductance calcium-activated potassium channels (K(Ca)) and current or molecular transfer via myoendothelial gap junctions underlies endothelium-derived hyperpolarization leading to vasodilation. The mechanism underlying the K(Ca) component of vasodilator activity and the

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