M6517

α,β-Methyleneadenosine 5′-triphosphate lithium salt

≥93% (HPLC), solid

• Synonym(s): AMP-CPP
• Empirical Formula (Hill Notation): C₁₁H₁₈N₅O₁₂P₃ · xLi⁺
• CAS Number: 104809-20-3
• Molecular Weight: 505.21 (free acid basis)
• MDL number: MFCD00148925
• UNSPSC Code: 41106305
• eCl@ss: 32160414
• PubChem Substance ID: 24277720
• NACRES: NA.77

Properties

• Quality Level: 200
• Assay: ≥93% (HPLC)
• form: solid
• color: white
• solubility: H₂O: 100 mg/mL
• storage temp.: −20°C
• SMILES string: [Li+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)CP(O)(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O
• InChI: 1S/C11H18N5O12P3.Li/c12-9-6-10(14-2-13-9)16(3-15-6)11-8(18)7(17)5(27-11)1-26-29(19,20)4-30(21,22)28-31(23,24)25;/h2-3,5,7-8,11,17-18H,1,4H2,(H,19,20)(H,21,22)(H2,12,13,14)(H2,23,24,25);/q;+1/p-1/t5-,7-,8-,11-;/m1./s1
• InChI key: NVHVREPTGDOYIC-YCSZXMBFSA-M
• Gene Information: human ... P2RX1(5023)

Description

Application

α,β-Methyleneadenosine 5′-triphosphate lithium salt has been used:

• as P2-purinoreceptor agonist (P2X), to analyse its effects on membrane conductance in the astrocytes of caudal nucleus
• as a P2X receptor agonist, to increase the calcium current in the neurons in satellite cells
• to determine the functional sensitivities of purinergic agonists on P2Y receptors in rat and to determine its effect on developing outer sulcus cells

Biochem/physiol Actions

P2 purinoceptor agonist that is more potent than ATP at the P2X subtype.

Features and Benefits

This compound is featured on the P2 Receptors: P2X Ion Channel Family and P2 Receptors: P2Y G-Protein Family pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Physical form

hygroscopic solid

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves