F8932

Fatostatin hydrobromide

≥98% (HPLC), powder

• Synonym(s): 25B11 hydrobromide, 4-[4-(4-methylphenyl)-2-thiazolyl]-2-propylpyridine hydrobromide, Fatostatin A hydrobromide; 2-(2-propylpyridin-4-yl)-4-p-tolylthiazole hydrobromide
• Empirical Formula (Hill Notation): C₁₈H₁₈N₂S·HBr
• CAS Number: 298197-04-3
• Molecular Weight: 375.33
• MDL number: MFCD00760867
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: light yellow to yellow
• solubility: DMSO: ≥10 mg/mL
• storage temp.: 2-8°C
• SMILES string: [s]1c(nc(c1)c3ccc(cc3)C)c2cc(ncc2)CCC.Br
• InChI: 1S/C18H18N2S.BrH/c1-3-4-16-11-15(9-10-19-16)18-20-17(12-21-18)14-7-5-13(2)6-8-14;/h5-12H,3-4H2,1-2H3;1H
• InChI key: RJCFNQZVFUMORB-UHFFFAOYSA-N

Description

General description

Fatostatin is a non-sterol diarylthiazole derivative. It prevents insulin-induced adipogenesis and lowers the amounts of fatty acid, triglyceride and low-density lipoprotein. Fatostatin has anti tumor and antimitotic properties.

Application

Fatostatin hydrobromide has been used:

• to study its anti-cancer activity and effects on mitotic microtubule spindle
• to study its effects on stomatal development
• to prevent SREBP cleavage-activating protein (SCAP)-mediated escort of sterol regulatory element-binding proteins (SREBPs)

Biochem/physiol Actions

Fatostatin hydrobromide is an SREBP inhibitor.

Fatostatin hydrobromide is an SREBP inhibitor. Fatostatin hydrobromide inhibits fat production and lowers glucose levels in mice by inhibiting SREBP (Sterol Regulatory Element Binding Proteins).

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable