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A7219

Sigma-Aldrich

L-Aspartic acid

from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%

Synonym(s):

(S)-(+)-Aminosuccinic acid, (S)-Aminobutanedioic acid

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About This Item

Linear Formula:
HO2CCH2CH(NH2)CO2H
CAS Number:
56-84-8
Molecular Weight:
133.10
Beilstein:
1723530
EC Number:
200-291-6
MDL number:
MFCD00002616
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24891191
NACRES:
NA.75

biological source

non-animal source

Agency

meets EP testing specifications
meets USP testing specifications

Assay

98.5-101.0%

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white to off-white

mp

>300 °C (dec.) (lit.)

solubility

1 M HCl: 100 mg/mL

SMILES string

N[C@@H](CC(O)=O)C(O)=O

InChI

1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1

InChI key

CKLJMWTZIZZHCS-REOHCLBHSA-N

Gene Information

human ... CA1(759) , CA2(760)
rat ... Grin2a(24409)

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General description

Aspartic acid(ASP)/aspartate, a non-essential amino acid, is naturally produced by mammals. ASP is one of the 20 building-block amino acids of proteins and has a one letter code, D. L-Aspartic acid can be manufactured industrially by an enzymatic process using the aspartase enzyme.

Application

L-Aspartic acid has been used:
  • as an aspartame (ASP) metabolite to determine acetylcholinesterase (AChE) activity in the hippocampal homogenate of suckling rats
  • as printed chemotaxis ligands to screen chemotaxis receptors with high-throughput technologies and verify the interactions with surface plasmon resonance (SPR) and nuclear magnetic resonance (NMR)
  • as a supplement in Dulbecco′s modified Eagle′s medium (DMEM) for supplementation assays of various cultured cell lines

Biochem/physiol Actions

Principal neurotransmitter for fast synaptic excitation.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Florinda Meléndez-Rodríguez et al.
Cell reports, 26(9), 2257-2265 (2019-02-28)
Cellular aspartate drives cancer cell proliferation, but signaling pathways that rewire aspartate biosynthesis to control cell growth remain largely unknown. Hypoxia-inducible factor-1α (HIF1α) can suppress tumor cell proliferation. Here, we discovered that HIF1α acts as a direct repressor of aspartate
Aspartic acid
Johnson EC
reference module in biomedical sciences (2017)
Christopher J Day et al.
Methods in molecular biology (Clifton, N.J.), 1512, 51-63 (2016-11-26)
Despite many years of research into bacterial chemotaxis, the only well characterized system to date is that of E. coli. Even for E. coli, the direct ligand binding had been fully characterized only for aspartate and serene receptors Tar and
Florinda Meléndez-Rodríguez et al.
Cell reports, 26(9), 2257-2265 (2019-02-28)
Cellular aspartate drives cancer cell proliferation, but signaling pathways that rewire aspartate biosynthesis to control cell growth remain largely unknown. Hypoxia-inducible factor-1α (HIF1α) can suppress tumor cell proliferation. Here, we discovered that HIF1α acts as a direct repressor of aspartate
Hongyu Ding et al.
Science advances, 7(47), eabk1023-eabk1023 (2021-11-18)
[Figure: see text].
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