A3785

5-Aminolevulinic acid hydrochloride

≥98%

• Synonym(s): δ-Aminolevulinic acid hydrochloride, 5-Amino-4-oxopentanoic acid hydrochloride, 5-Aminolaevulinic acid hydrochloride, ALA
• Linear Formula: NH₂CH₂C(O)CH₂CH₂COOH · HCl
• CAS Number: 5451-09-2
• Molecular Weight: 167.59
• Beilstein: 3690651
• EC Number: 226-679-5
• MDL number: MFCD00012869
• UNSPSC Code: 12352209
• PubChem Substance ID: 24890811
• NACRES: NA.26

Properties

• Quality Level: 300
• Assay: ≥98%
• form: powder
• technique(s): ligand binding assay: suitable
• mp: 150 °C
• storage temp.: −20°C
• SMILES string: Cl[H].NCC(=O)CCC(O)=O
• InChI: 1S/C5H9NO3.ClH/c6-3-4(7)1-2-5(8)9;/h1-3,6H2,(H,8,9);1H
• InChI key: ZLHFONARZHCSET-UHFFFAOYSA-N

Description

Application

5-Aminolevulinic acid hydrochloride has been used to activate or inhibit heme biosynthesis in HeLa and K562 cell lines. It has also been used in photodynamic therapy for A431 tumor bearing mice.

Biochem/physiol Actions

5-Aminolevulinic acid (5-ALA) is an intermediate in heme biosynthesis and is useful in cancer treatment. It is a non-protein amino acid. 5-ALA also has applications in the field of agriculture. It is being studied as an inducing reagent for protoporphyrin IX (PPIX) dependent fluorescence diagnosis of metastatic lymph nodes. 5-ALA is used for photodynamic therapy of diseases, such as Paget′s disease and HPV infection-associated cervical condylomata acuminata.

Intermediate in heme biosynthesis.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable