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418M-1

Sigma-Aldrich

Claudin 7 (5D10F3) Mouse Monoclonal Antibody

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.41
clone:
5D10F3, monoclonal
application:
IHC (p)
species reactivity:
human
technique(s):
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
citations:
4

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

5D10F3, monoclonal

description

(For In Vitro Diagnostic Use in Select Regions (See Chart))

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (418M-14)
vial of 0.5 mL concentrate (418M-15)
bottle of 1.0 mL predilute (418M-17)
vial of 1.0 mL concentrate (418M-16)
bottle of 7.0 mL predilute (418M-18)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

isotype

IgG2aκ

control

chromophobe renal cell carcinoma

shipped in

wet ice

storage temp.

2-8°C

visualization

membranous

Gene Information

human ... CLDN7(1366)

General description

Claudin-7 is a transmembrane protein involved in the formation of tight junctions between epithelial cells.1 Tight junctions restrict lateral diffusion of lipids and membrane proteins which physically define the border between the apical and basolateral compartments of epithelial cells. The Claudin family of proteins has been implicated in the pathogenesis of various human neoplasms. The differential diagnosis of chromophobe renal cell carcinoma (RCC) and oncocytoma is difficult by light microscopy, and yet important as chromophobe RCC is malignant, whereas oncocytoma is benign.2 Membranous claudin-7 expression was detected in 67-100% chromophobe RCCs, compared with 0-7% clear cell RCCs, 28-90% papillary RCCs, and 26-45% oncocytomas.1,3 Distal nephron (distal convoluted tubule and thick ascending limb of Henle′s loop) epithelium showed strong membranous staining in 100% (174/174) of the cases.4

Quality


IVD
IVD
IVD
RUO

Linkage

Claudin 7 Positive Control Slides, Product No. 418S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
1508906A-Z
1508905A-Z

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Yoo Duk Choi et al.
Journal of Korean medical science, 22(2), 305-310 (2007-04-24)
Claudin-7 has recently been suggested to be a distal nephron marker. We tested the possibility that expression of claudin-7 could be used as a marker of renal tumors originating from the distal nephron. We examined the immunohistochemical expression of claudin-7
Lin Li et al.
International journal of clinical and experimental pathology, 1(1), 57-64 (2008-09-12)
Claudins, a family of tight junction-related transmembrane proteins, have been implicated in the pathogenesis of various human neoplasms. Expression of claudin-7 was increased in chromophobe renal cell carcinoma in a recent oligonucleotide microarray study. We studied the expression of claudin-7
Adeboye O Osunkoya et al.
Human pathology, 40(2), 206-210 (2008-09-19)
Claudin-7 and claudin-8 code for tight junction proteins expressed in distal nephron epithelium. In a recent oligonucleotide microarray study, we identified claudin-7 and claudin-8 as candidate markers to distinguish chromophobe renal cell carcinoma from other renal tumors, including oncocytoma. Distinction
Christopher D Hornsby et al.
Archives of pathology & laboratory medicine, 131(10), 1541-1546 (2007-10-10)
The differential diagnosis of eosinophilic renal tumors can be difficult by light microscopy. In particular, chromophobe renal cell carcinoma (RCC) is difficult to distinguish from oncocytoma. This differential diagnosis is important because chromophobe RCC is malignant, whereas oncocytoma is benign.

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