P4722

Pyridoxine hydrochloride

meets USP testing specifications

• Synonym(s): Adermine hydrochloride, PN HCl, Pyridoxol hydrochloride, Vitamin B₆ hydrochloride
• Empirical Formula (Hill Notation): C₈H₁₁NO₃ · HCl
• CAS Number: 58-56-0
• Molecular Weight: 205.64
• Beilstein: 3632435
• EC Number: 200-386-2
• MDL number: MFCD00012807
• UNSPSC Code: 12352205
• eCl@ss: 34058008
• PubChem Substance ID: 24898493
• NACRES: NA.21

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• Agency: USP/NF; meets USP testing specifications
• Assay: 98.0-102.0% dry basis
• form: powder
• color: white
• mp: 214-215 °C (lit.)
• application(s): pharmaceutical (small molecule)
• SMILES string: Cl[H].Cc1ncc(CO)c(CO)c1O
• InChI: 1S/C8H11NO3.ClH/c1-5-8(12)7(4-11)6(3-10)2-9-5;/h2,10-12H,3-4H2,1H3;1H
• InChI key: ZUFQODAHGAHPFQ-UHFFFAOYSA-N

Description

General description

Vitamin B group is water-soluble and exists in six forms namely the pyridoxal, pyridoxine, pyridoxamine, pyridoxamine 5′-phosphate, pyridoxine 5′-phosphate and pyridoxal 5′-phosphate. The food sources of vitamin B₆ include grains, nuts, fruits, vegetables and meat.

Application

Pyridoxine hydrochloride has been used to test its neuroprotective functionality in traumatic brain injury (TBI) rats. It has also been used as a reference standard to quantify vitamin B₆ in feed and digesta samples using high-performance liquid chromatography(HPLC).

Biochem/physiol Actions

Pyridoxine plays a key role in metabolism both carbohydrates and amino acids. It supports brain development and its deficiency levels may lead to depletion of γ-aminobutyric acid (GABA) levels. Pyridoxine catalyzes the neurotransmitter biosynthesis like dopamine and serotonin. Pyridoxine in excess or deficient may lead to neuropathy.

Safety Information

• Pictograms: GHS05
• Signal Word: Danger
• Hazard Statements: H318
• Precautionary Statements: P280 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves