Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

26210

Sigma-Aldrich

3-Chloropropionyl chloride

purum, ≥98.0% (GC)

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Linear Formula:
ClCH2CH2COCl
CAS Number:
625-36-5
Molecular Weight:
126.97
Beilstein:
635814
EC Number:
210-890-4
MDL number:
MFCD00000747
UNSPSC Code:
12352100
PubChem Substance ID:
329752857

grade

purum

Assay

≥98.0% (GC)

refractive index

n20/D 1.457 (lit.)
n20/D 1.457

bp

143-145 °C (lit.)

density

1.324 g/mL at 20 °C
1.33 g/mL at 25 °C (lit.)

SMILES string

ClCCC(Cl)=O

InChI

1S/C3H4Cl2O/c4-2-1-3(5)6/h1-2H2

InChI key

INUNLMUAPJVRME-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Application

3-Chloropropionyl chloride has been used in:
  • microwave-promoted liquid-phase synthesis of 3,5-disubstituted 2-thioxotetrahydropyrimidin-4-ones
  • preparation of hydrophilic and macroporous polymer resins modified with isothiocyanate groups
  • synthesis of diethylaminopropionamido-hydroxy-anthraquinones, which are potential anticancer agents

Pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

Signal Word

Danger

Hazard Statements

H290,H302,H314,H330

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1A

Supplementary Hazards

EUH014

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 1

Flash Point(F)

158.9 °F - closed cup

Flash Point(C)

70.5 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
1356354V
1356354
1352735
369067/1
1185425

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Wen-Ben Yeh et al.
Molecular diversity, 7(2-4), 185-198 (2004-02-12)
An efficient, microwave-assisted method for the liquid-phase combinatorial synthesis of 3,5-disubstituted thiohydantoins and 3,5-disubstituted 2-thioxotetrahydropyrimidin-4-ones has been developed. In synthesizing thiohydantoins, Fmoc-protected amino acids were coupled with polymer support and then deprotected to give primary amines. While in synthesizing thioxotetrahydropyrimidinones
M Hasegawa et al.
Biotechnology and bioengineering, 36(3), 219-223 (1990-07-01)
Hydrophilic and macroporous polymer resins composed of glycerylmethacrylate, styrene, and divinylbenzene were quite easily modified with isothiocyanate groups using a Friedel-Crafts reaction with 3-chloropropionyl chloride and subsequent nucleophilic reaction with KSCN. Alkaline phosphatase and trypsin could be covalently bound to
C Antonello et al.
Archiv der Pharmazie, 322(9), 541-544 (1989-09-01)
A number of new 9,10-anthracenediones were obtained, bearing one or two hydroxyl groups and one positively charged side chain at different positions of the aromatic ring system (compounds 1-5 in Chart 1). These derivatives resemble the anticancer agents mitoxantrone and

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service