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MAB2239

Sigma-Aldrich

Anti-Tau Antibody, clone Tau 7

clone Tau 7, from mouse

Synonym(s):

G protein beta1/gamma2 subunit-interacting factor, Neurofibrillary tangle protein, Paired helical filament-tau, microtubule-associated protein tau, microtubule-associated protein tau, isoform 4

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

Tau 7, monoclonal

species reactivity

human, rat

technique(s)

western blot: suitable

isotype

IgG1κ

NCBI accession no.

NP_001116538.1

UniProt accession no.

P10636

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... MAPT(4137)
rat ... Mapt(29477)

General description

Microtubule Associated Proteins, or MAPS, bind to the tubulin subunits of microtubule structures and regulate their functional stability. In the cell MAPs bind to monomer and multimerized tubulin. MAP binding to multimerized tubulin further stabilizes the formation of higher order microtubulin structures. MAP binding to microtubule structures is mediated through phosphorylation through Microtubule Affinity Regulated Kinase (MARK). Phosphorylation releases MAPs bound to microtubules, destabilizing the structure, driving it toward disassembly. There are predominately two MAP types, I, II. Type II MAP includes MAP2, MAP4, and tau and are found in nervous tissue. Six tau isoforms exist in brain tissue, and they are distinguished by their number of binding domains. Three isoforms have three binding domains and the other three have four binding domains. The binding domains are located in the carboxy-terminus of the protein and are positively-charged (allowing it to bind to the negatively-charged microtubule). The isoforms with four binding domains are better at stabilizing microtubules than those with three binding domains.

Specificity

Cat. # MAB2239 recognizes the C-terminus region of Tau.
Reactivity with other species has not been determined.

Application

This Anti-Tau Antibody, clone Tau 7 is validated for use in WB for the detection of Tau.

Quality

Western Blot:

Target description

50-68 kDa

Physical form

Format: Purified

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Nicotinamide mononucleotide adenylyltransferase 1 gene NMNAT1 regulates neuronal dendrite and axon morphogenesis in vitro.
Hong Zhao,Jing-Yu Zhang,Zi-Chao Yang,Ming Liu,Bao-Zhi Gang,Qing-Jie Zhao
Chinese Medical Journal (English Edition) null
Peleg M Horowitz et al.
Biochemistry, 45(42), 12859-12866 (2006-10-18)
The polymerization of the microtubule-associated protein, tau, into insoluble filaments is a common thread in Alzheimer's disease and in a variety of frontotemporal dementias. The conformational change required for tau to transition from an extended monomeric state to a filamentous
M Goedert et al.
Neuron, 3(4), 519-526 (1989-10-01)
We have determined the sequences of isoforms of human tau protein, which differ from previously reported forms by insertions of 29 or 58 amino acids in the amino-terminal region. Complementary DNA cloning shows that the insertions occur in combination with

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