AP130P
Goat Anti-Mouse IgG & IgM Antibody, HRP conjugate
0.8 mg/mL, Chemicon®
Synonym(s):
Goat Anti-Mouse IgG Antibody
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.46
Recommended Products
biological source
goat
Quality Level
conjugate
peroxidase conjugate
antibody form
F(ab′)2 fragment of affinity isolated antibody
antibody product type
secondary antibodies
clone
polyclonal
species reactivity
mouse
manufacturer/tradename
Chemicon®
concentration
0.8 mg/mL
technique(s)
ELISA: suitable
western blot: suitable
shipped in
wet ice
target post-translational modification
unmodified
General description
Immunoglobulin G (IgG) is the most abundant immunoglobulin in the human serum. IgM constitutes 5-10% of total serum immunoglobulins. These immunoglobulins comprise four polypeptide chains with two heavy (H) chains and two light (L) chains. These polypeptide chains are inter-linked by disulfide bonds. IgM is a highly conserved antibody in vertebrates. IgM exists as a pentamer. Both IgG and IgM are secreted by B cells.
Application
Goat Anti-Mouse IgG & IgM Antibody, HRP conjugate has been used in western blotting(1:400) and immunofluorescence (1:500)
Biochem/physiol Actions
IgG facilitates antibody-dependent cell-mediated cytotoxicity (ADCC). It also aids in the activation of the classical pathway of the complement system. IgG neutralizes virus particles and toxins. IgM, an antibody that is expressed early during an immune response, aids in engulfing apoptotic cells. It exhibits polyreactive and autoreactive functionality. IgM induces tissue homeostasis by mediating the clearance of tissue-based molecules. Lower levels of IgM in serum are associated with increased autoimmune response and a higher risk of developing infections.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Hongsheng Wang et al.
Frontiers in immunology, 7, 99-99 (2016-03-26)
Most natural IgM antibodies are encoded by germline Ig sequences and are produced in large quantities by both mice and humans in the absence of intentional immunization. Natural IgM are reactive with many conserved epitopes, including those shared by microorganisms
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