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Key Documents

8.00683

Sigma-Aldrich

Succinic anhydride

for synthesis

Synonym(s):

Succinic anhydride

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About This Item

Empirical Formula (Hill Notation):
C4H4O3
CAS Number:
108-30-5
Molecular Weight:
100.07
MDL number:
MFCD00005525
UNSPSC Code:
12352115
EC Index Number:
203-570-0
NACRES:
NA.22

vapor pressure

1.3 hPa ( 92 °C)

Quality Level

200

form

crystals

autoignition temp.

480 °C

potency

1510 mg/kg LD50, oral (Rat)

pH

2.7 (10 g/L in H2O)

bp

261 °C/1013 hPa

mp

116-120 °C

transition temp

flash point 157 °C

solubility

62.9 g/L (Hydrolysis)

density

1.23 g/cm3 at 20 °C

bulk density

550‑600 kg/m3

storage temp.

2-30°C

InChI

1S/C4H4O3/c5-3-1-2-4(6)7-3/h1-2H2

InChI key

RINCXYDBBGOEEQ-UHFFFAOYSA-N

Application

  • Enhanced antimicrobial fibers: Succinic anhydride is utilized in the conjugation of chitosan with Harakeke and Hemp fibers to produce antimicrobial fibers, which significantly increase their utility in medical and hygiene products (Barker et al., 2024).
  • Antitumor diterpenoids: Succinic anhydride is integral to synthesizing new clerodane diterpenoids from Callicarpa pseudorubella, which show potential antitumor proliferative activity, expanding its applications in cancer research (Pan et al., 2024).
  • Nanogel delivery systems: It plays a role in developing nanogel delivery systems for cationic peptides, enhancing the delivery of therapeutic agents and showcasing its versatility in pharmaceutical delivery systems (Mørck Nielsen et al., 2024).

Analysis Note

Assay (morpholine method): ≥ 98,0 %(m)
Identity (IR): conforms
Melting range (lower value): ≥ 116 °C
Melting range (upper value): ≤ 120 °C

Signal Word

Danger

Hazard Statements

H302 - H314 - H317 - H334

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

Storage Class Code

8A - Combustible, corrosive hazardous materials

WGK

WGK 1

Flash Point(F)

314.6 °F

Flash Point(C)

157 °C

Certificates of Analysis (COA)

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Ananthakrishnan Soundaram Jeevarathinam et al.
Angewandte Chemie (International ed. in English) (2019-12-17)
We report a new approach to monitor drug release from nanocarriers via a paclitaxel-methylene blue conjugate (PTX-MB) with redox activity. This construct is in a photoacoustically silent reduced state inside poly(lactic-co-glycolic acid) (PLGA) nanoparticles (PTX-MB@PLGA NPs). During release, PTX-MB is

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