700052P
Avanti
22(R)-hydroxycholesterol-d7
Avanti Research™ - A Croda Brand
Synonym(s):
25,26,26,26,27,27,27-heptadeuterocholest-5-ene-3β,22R-diol
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About This Item
Empirical Formula (Hill Notation):
C27H39O2D7
CAS Number:
Molecular Weight:
409.70
MDL number:
UNSPSC Code:
41141804
NACRES:
NA.25
description
cholest-5-ene-3β,22(R)-diol-d7
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (700052P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
application(s)
lipidomics
metabolomics
shipped in
dry ice
storage temp.
−20°C
General description
22(R)-hydroxycholesterol is a diastereomer of 22(S)-hydroxycholesterol. It is present in the neonate brain. 22(R)-hydroxycholesterol-d7 is a deuterated form of 22(R)-hydroxycholesterol.
Biochem/physiol Actions
22(R)-hydroxycholesterol (22(R)-HC) is a liver X receptor (LXR) ligand and is a key for the receptor activation.. 22(R)-HC promotes mesenchymal stem cell osteogenesis along with other oxysterols. It also regulates cholesterol homeostasis and suppresses prostate tumor progression. Low levels of 22(R)-HC is observed in Alzheimer′s disease and may be implicated in neuroinflammation and neurodegenerative diseases.
Packaging
5 mL Amber Glass Screw Cap Vial (700052P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
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