N3386

D-(+)-Neopterin

≥97.5% (sum of enantiomers, HPLC)

• Synonym(s): D-erythro-Neopterin
• Empirical Formula (Hill Notation): C₉H₁₁N₅O₄
• CAS Number: 2009-64-5
• Molecular Weight: 253.21
• Beilstein: 89070
• EC Number: 217-924-7
• MDL number: MFCD00042801
• UNSPSC Code: 12352005
• PubChem Substance ID: 57654449
• NACRES: NA.22

Properties

• Assay: ≥97.5% (sum of enantiomers, HPLC)
• form: powder
• storage temp.: 2-8°C
• SMILES string: Nc1nc(O)c2nc(cnc2n1)[C@H](O)[C@H](O)CO
• InChI: 1S/C9H11N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h1,4,6,15-17H,2H2,(H3,10,11,13,14,18)/t4-,6+/m1/s1
• InChI key: BMQYVXCPAOLZOK-XINAWCOVSA-N

Description

General description

D-(+)-Neopterin is a pteridine derivative, naturally found in Dictyostelium discoideum. It is found in significant amounts in the urine of cancer patients.

Application

D-(+)-Neopterin has been used as a NADPH oxidase inhibitor while assessing the ability of NADPH oxidases in breast cancer cells to produce reactive oxygen species (ROS). [NADPH= nicotinamide adenine dinucleotide phosphate]

Biochem/physiol Actions

Pterin cofactor; precursor of BH₄ (tetrahydrobiopterin).

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves