F5062

Fmoc-Lys(Me)₃-OH Chloride

≥97%, for peptide synthesis

• Synonym(s): Fmoc-Lys(Me₃Cl)-OH, N-alpha-Fmoc-N-alpha-trimethyl-N-L-lysine · chloride
• Empirical Formula (Hill Notation): C₂₄H₃₁ClN₂O₄
• CAS Number: 201004-29-7
• Molecular Weight: 446.97
• MDL number: MFCD00672333
• UNSPSC Code: 12352209
• NACRES: NA.26

Properties

• Product Name: Fmoc-Lys(Me)₃-OH Chloride, ≥97%
• Quality Level: 100
• Assay: ≥97%
• form: liquid
• reaction suitability: reaction type: Fmoc solid-phase peptide synthesis
• application(s): peptide synthesis
• functional group: Fmoc
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: Cl.[N+](CCCC[C@H](N=C([O-])OCC1c2c(cccc2)c3c1cccc3)C(=O)O)(C)(C)C
• InChI: 1S/C24H30N2O4.ClH/c1-26(2,3)15-9-8-14-22(23(27)28)25-24(29)30-16-21-19-12-6-4-10-17(19)18-11-5-7-13-20(18)21;/h4-7,10-13,21-22H,8-9,14-16H2,1-3H3,(H-,25,27,28,29);1H/t22-;/m0./s1
• InChI key: XUJRNPVABVHOAJ-FTBISJDPSA-N

Description

General description

Fmoc protected N-trimethyl lysine

Application

Fmoc-Lys(Me)₃-OH chloride is one of the common N-terminal protected reagents used in the peptide synthesis. Some of the reported examples are:

• Synthesis of peptide linkers for monoclonal antibody-auristatin F conjugates.
• Preparation of multifunctional reagents with enhanced ionization properties for the analysis of protein modification in human cells and dynamic profiling of protein lipidation.
• Sequential peptide ligation to synthesize histone H3 containing a trimethyl lysine residue, with modified tail region.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable