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D8402

Sigma-Aldrich

1,2-Diacetylhydrazine

98%

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About This Item

Linear Formula:
CH3CONHNHCOCH3
CAS Number:
3148-73-0
Molecular Weight:
116.12
EC Number:
221-576-1
MDL number:
MFCD00008673
UNSPSC Code:
12352100
PubChem Substance ID:
24894211
NACRES:
NA.22

Assay

98%

form

powder

bp

209 °C/15 mmHg (lit.)

mp

138-140 °C (lit.)

SMILES string

CC(=O)NNC(C)=O

InChI

1S/C4H8N2O2/c1-3(7)5-6-4(2)8/h1-2H3,(H,5,7)(H,6,8)

InChI key

ZLHNYIHIHQEHJQ-UHFFFAOYSA-N

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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E B Bhalerao et al.
Indian journal of physiology and pharmacology, 29(2), 83-88 (1985-04-01)
Patients suffering from pulmonary tuberculosis were investigated for the levels of isoniazid (INH) and its metabolites viz. acetyl-INH, mono and diacetyl hydrazines and ammonia. It was observed that 50% of the patients are slow inactivators of INH and almost all
S V Bhide et al.
Cancer letters, 23(2), 235-240 (1984-06-01)
Two hydrazine derivatives, monoacetyl hydrazine (MAH) and diacetyl hydrazine (DAH), have been tested for mutagenic response in the Salmonella/mammalian microsome assay and micronucleus test. MAH but not DAH, increased the revertant mutants in TA100 and TA1535 and also increased the
J A Timbrell et al.
Human toxicology, 3(6), 485-495 (1984-12-01)
The urinary metabolite profile of isoniazid has been studied in patients receiving the drug as therapy for tuberculosis and the profile in patients suffering liver damage due to isoniazid compared with that in control patients. There were no consistent differences
E B Bhalerao et al.
Indian journal of physiology and pharmacology, 29(3), 133-138 (1985-07-01)
Effect of isoniazid (INH) and its metabolites e.g. mono and diacetyl hydrazines (MAH and DAH respectively) was studied on circulating and tissue folates in mice (a species susceptible to INH tumorigenicity) and rats (a species resistant to INH carcinogenicity). It
Ramachandran Azhakar et al.
Dalton transactions (Cambridge, England : 2003), 41(5), 1529-1533 (2011-12-14)
The reaction of N-heterocyclic silylene (NHSi) L [L = CH{(C[double bond, length as m-dash]CH(2))(CMe)(2,6-iPr(2)C(6)H(3)N)(2)}Si] with benzoylhydrazine, 1,2-dicarbethoxyhydrazine, 1,2-diacetylhydrazine and 1,2-bis(tert-butoxycarbonyl)hydrazine in 1 : 1 molar ratio resulted in compounds 1-4 with an almost quantitative yield and five coordinate silicon atoms.
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