95541

Chlorotrimethylsilane

produced by Wacker Chemie AG, Burghausen, Germany, ≥99.0% (GC)

• Synonym(s): Silane M3, TMCS, Trimethylchlorosilane, Trimethylsilyl chloride
• Linear Formula: (CH₃)₃SiCl
• CAS Number: 75-77-4
• Molecular Weight: 108.64
• Beilstein: 1209232
• EC Number: 200-900-5
• MDL number: MFCD00000502
• UNSPSC Code: 12352302
• PubChem Substance ID: 57653685
• NACRES: NA.22

Properties

• grade: produced by Wacker Chemie AG, Burghausen, Germany
• Quality Level: 200
• vapor density: 3.7 (vs air)
• vapor pressure: 100 mmHg ( 25 °C)
• Assay: ≥99.0% (GC)
• form: liquid
• autoignition temp.: 752 °F
• expl. lim.: 6.4 %
• refractive index: n20/D 1.387 (lit.)
• bp: 57 °C (lit.)
• mp: −40 °C (lit.)
• density: 0.856 g/mL at 25 °C (lit.)
• SMILES string: C[Si](C)(C)Cl
• InChI: 1S/C3H9ClSi/c1-5(2,3)4/h1-3H3
• InChI key: IJOOHPMOJXWVHK-UHFFFAOYSA-N

Description

General description

Chlorotrimethylsilane is a chloro-organosilane compound mainly used for silylation reactions.

Application

Possible usages of chlorotrimethylsilane:

• Chloromethylation of polysulfones (PSUs).
• Activation of lithium hydride to convert it into a hydride source for the reductive silylation of carbonyl compounds.
• Chlorotrimethylsilane/lithium bromide forms an effective reagent for the conversion of alcohols to bromides.
• Chlorotrimethylsilane is a non-toxic alternative to mercuric chloride in activating in samarium-promoted cyclopropanation of both allylic and α-allenic alcohols.

It is also used in Fisher glycosylation.

Other Notes

Silane M3

prices for bulk quantities on request

Safety Information

• Pictograms: GHS02,GHS05,GHS06
• Signal Word: Danger
• Hazard Statements: H225 - H301 + H331 - H312 - H314
• Precautionary Statements: P210 - P233 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1A
• Supplementary Hazards: EUH014
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): -18.4 °F - closed cup
• Flash Point(C): -28 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves