930539

(S,R,S)-AHPC-Me-C₅-COOH

≥95%

• Synonym(s): 6-{[(2S)-1-[(2S,4R)-4-Hydroxy-2-{[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]carbamoyl}pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}hexanoic acid, 7-(((S)-1-((2S, 4R)-4-Hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptanoic acid, L-Prolinamide, N-(6-carboxy-1-oxohexyl)-3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)
• Empirical Formula (Hill Notation): C₃₀H₄₂N₄O₆S
• CAS Number: 2229976-21-8
• Molecular Weight: 586.74
• MDL number: MFCD33029229
• UNSPSC Code: 12352100
• NACRES: NA.22

Properties

• ligand: VH032
• Quality Level: 100
• Assay: ≥95%
• form: powder
• functional group: carboxylic acid
• storage temp.: 2-8°C

Description

Application

(S,R,S)-AHPC-Me-C₅-COOH is a functionalized von-Hippel-Lindau (VHL) ligand with a terminal carboxyl group, allowing rapid conjugation of amine containing linkers. A basic building block for development of a protein degrader library.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation


Protein Degrader Building Blocks

Other Notes

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable